Effect of Ethyl Acetate Fraction of Terminalia ivorensis on Ethanol Induced Infertility in Male Rats

Background: This research investigates the Effect of Ethyl Acetate Fraction of Terminalia ivorensis on Ethanol Induced Infertility in Male Rats. Infertility is the inability to conceive after one year of unprotected intercourse for couples under 35, or after six months for those over 35. It affects both men and women, with various factors contributing to the condition. Terminalia ivorensis has been claimed from traditional healers for the treatment of infertility hence the study.

Method: Quantitative phytochemical analysis, toxicity test and other biochemical analysis was carried out using standard method.

Results: Seven hundred grammes (700 g) of dried crude sample of Ethyl acetate Fraction of Terminalia ivorensis leaves powder gave a percentage yield of 6.28%. The study revealed that flavonoids, tannins, and phenols were present in high concentration, alkaloids, terpenoids and glycosides were present in moderate concentration, whereas saponins, steroids and hydrogen cyanide were present in low concentration. The toxicity result showed that the extract was not toxic even at the highest dosage (5000 mg/kg body weight) administered, indicating that the extract is safe for consumption. The results shown in the Table 3 indicates that groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight of extract significantly (P < 0.05) increased in testosterone level when compared to positive control; whereas groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight of extract showed significantly (P < 0.05) higher in LH and FSH when compared with positive control. The results in the Table 3 showed that groups treated with 200mg/kg,400mg/kg and 600kg/kg body weight of extract significantly (P < 0.05) decreases in sluggish, and dead sperm level when compared with positive control whereas groups treated with 200mg/kg,400mg/kg and 600mg/kg body weight significantly (P < 0.05) increased active, sperm count and normal sperm when compared with positive control.

Conclusion: The plant extract has ant infertility properties and can be recommend as an alternative therapy for infertility in male.